SRRM1 and ABI1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SRRM1	ABI1
Name		serine and arginine repetitive matrix 1	abl interactor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Filopodium Growth Cone SCAR Complex Cell Leading Edge Filopodium Tip Cell Projection Neuron Projection Synapse Extracellular Exosome Actin-based Cell Projection
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome	Somitogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Megakaryocyte Development Dendrite Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
GWAS		Adult body size ( 32376654 ) Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Male-pattern baldness ( 28196072 ) Systolic blood pressure ( 29208002 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: ABI1 CLK1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 SRRM4 YWHAG	67 interacting genes: ABL1 AKT1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2
Entrez ID		10250	10006
HPRD ID		10441	04336
Ensembl ID		ENSG00000133226	ENSG00000136754
Uniprot IDs		A0A0S2Z4W1 A0A0S2Z4Z6 A0A994J4Y3 A0A994J7H1 A0A994J7V4 B7Z7U0 Q8IYB3	A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs		1MP1 6FF4 6FF7 7ABG 7ABH 7ABI 7DVQ 8I0P 8I0R	7LXE
GO Terms Enriched among Interactors		Regulation Of RNA Splicing Nuclear Speck Regulation Of Primary Metabolic Process Nucleus Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of Metabolic Process Macromolecule Metabolic Process RNA Binding MRNA Metabolic Process Kinase Activity Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Double-strand Break Repair Protein Serine/threonine/tyrosine Kinase Activity Postsynaptic Cytosol Positive Regulation Of Viral Genome Replication MRNA Processing Regulation Of Gene Expression RNA Metabolic Process RNA Processing Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Protein Targeting Nucleoplasm Negative Regulation Of Translational Initiation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Regulation Of DNA Repair Protein Modification Process Protein Stabilization Cis-trans Isomerase Activity Positive Regulation Of Viral Process Identical Protein Binding Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Phosphorylation Protein Localization To Vacuole Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nucleic Acid Metabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity ATP Binding	Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Cytoskeleton Organization Actin Binding Cell Projection Regulation Of Actin Filament Length Regulation Of Cellular Component Size Cell Projection Organization Cytoskeleton Organization Regulation Of Actin Filament Polymerization Lamellipodium Postsynaptic Density Regulation Of Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Organelle Organization Cytoplasm Supramolecular Fiber Organization SCAR Complex Protein Binding Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Translational Initiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Cadherin Binding Synapse Positive Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Actin Filament Polymerization Organelle Organization Cytoskeleton Cytosol Rac Protein Signal Transduction Negative Regulation Of Supramolecular Fiber Organization Actin Polymerization Or Depolymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anchoring Junction Positive Regulation Of Cellular Component Biogenesis SH3 Domain Binding Positive Regulation Of Cellular Component Organization Cell Cortex Profilin Binding