CALCOCO2 and FBXL18

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid), HPRD (two hybrid)

		CALCOCO2	FBXL18
Name		calcium binding and coiled-coil domain 2	F-box and leucine rich repeat protein 18
Structure			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding	None
	Biological Process	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		None	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Chronotype ( 30696823 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Serum alkaline phosphatase levels ( 33547301 ) Type 2 diabetes ( 29358691 29632382 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )	Basophil percentage of white cells ( 32888494 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) High light scatter reticulocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315 ) Relative hand skill in reading disability ( 24068947 )
Interacting Genes		182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80	22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		10241	80028
HPRD ID		06846	07753
Ensembl ID		ENSG00000136436	ENSG00000155034
Uniprot IDs		Q13137	Q96D16 Q96ME1
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA	Not available
GO Terms Enriched among Interactors		Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule	Cytoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Thioesterase Binding Cytoskeleton Proteasomal Protein Catabolic Process Transcription Factor Binding Keratin Filament Ubiquitin Ligase Complex Symbiont Entry Into Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Tumor Necrosis Factor Receptor Binding Identical Protein Binding Biological Process Involved In Interaction With Host Protein Catabolic Process Intermediate Filament Transcription Regulator Inhibitor Activity Proteolysis Involved In Protein Catabolic Process