FLOT1 and CAPN10

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		FLOT1	CAPN10
Name		flotillin 1	calpain 10
Structure			No pdb structure
GO Annotations	Cellular Component	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	SNARE Binding Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Insulin Secretion Positive Regulation Of Intracellular Transport Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of D-glucose Import Type B Pancreatic Cell Apoptotic Process Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Degradation of the extracellular matrix
Diseases		None	Type II diabetes mellitus
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Cutaneous lupus erythematosus ( 25827949 ) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311 ) General cognitive ability ( 29844566 ) Handedness (non-right-handed vs right-handed) ( 31504236 ) Hip circumference adjusted for BMI ( 34021172 ) Schizophrenia ( 30285260 ) Sleep duration ( 25469926 ) Ulcerative colitis ( 20848476 )	No GWAS studies recorded
Interacting Genes		26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL	5 interacting genes: EFNB1 FANCC FLOT1 PSMA7 SHD
Entrez ID		10211	11132
HPRD ID		06105	05595
Ensembl ID		ENSG00000137312	ENSG00000142330
Uniprot IDs		O75955 Q5ST80	Q9HC96
PDB IDs		9BQ2	Not available
GO Terms Enriched among Interactors		Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding	None