CALCRL and CALCA

Number of citations: 0 (PubMedID 9620797)
Data Source: HPRD (in vivo, in vitro)

		CALCRL	CALCA
Name		calcitonin receptor like receptor	calcitonin related polypeptide alpha
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Calcium Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Transport Receptor Internalization Smooth Muscle Cell Proliferation Cellular Response To Sucrose Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Vascular Associated Smooth Muscle Cell Proliferation	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Zavegepant Atogepant	Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
GWAS		A body shape index ( 34021172 ) Aspartate aminotransferase levels ( 33547301 ) Body mass index ( 25673413 ) Body size at age 10 ( 32376654 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Periventricular white matter hyperintensities ( 32517579 ) Resting heart rate ( 27798624 ) Serum immune biomarker levels ( 32066700 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 25673412 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 ) White blood cell count ( 32888494 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Diverticular disease ( 30177863 ) Hip circumference adjusted for BMI ( 34021172 ) Vitamin D levels ( 25208829 )
Interacting Genes		6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		10203	796
HPRD ID		11809	00238
Ensembl ID		ENSG00000064989	ENSG00000110680
Uniprot IDs		Q16602	P01258 P06881
PDB IDs		3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 8AX5 8AX6 8AX7	2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC
GO Terms Enriched among Interactors		Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Endocytosis Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Import Into Cell Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Coreceptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Antifungal Humoral Response Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis Vesicle-mediated Transport G Protein-coupled Receptor Internalization Response To Yeast Regulation Of Vasculogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Regulation Of Blood Pressure Protein Localization To Plasma Membrane Receptor Complex Protein Localization To Cell Periphery Calcium Ion Transport Vascular Process In Circulatory System Regulation Of Vascular Permeability Protein Localization To Membrane Circulatory System Process Defense Response To Fungus Cellular Response To Hormone Stimulus Response To Fungus Antibacterial Humoral Response Vasculogenesis Signal Transduction Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer DNA Polymerase III Complex Defense Response To Gram-negative Bacterium Positive Regulation Of Biosynthetic Process Muscle Cell Development	Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis