MPHOSPH9 and SVIL

Number of citations: 81 (PubMedID 20309963)
Data Source: BioGRID (two hybrid)

		MPHOSPH9	SVIL
Name		M-phase phosphoprotein 9	supervillin
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Centrosome Centriole Cytoskeleton Membrane	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction
	Molecular Function	Protein Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cilium Assembly	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development
GWAS		A body shape index ( 34021172 ) Albumin-globulin ratio ( 29403010 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Educational attainment ( 25201988 ) Hip circumference adjusted for BMI ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Multiple sclerosis ( 19525953 ) Plasma anti-thyroglobulin levels ( 29678681 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 ) Schizophrenia ( 23974872 30285260 29483656 28991256 25056061 ) Tourette syndrome ( 30818990 ) Type 2 diabetes ( 30297969 29632382 24509480 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Venous thromboembolism ( 31420334 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Bone fracture in osteoporosis ( 28580392 ) Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Estimated glomerular filtration rate ( 31152163 ) Lung function (FEV1/FVC) ( 28166213 ) Metabolite levels ( 23823483 ) Neurofibrillary tangles ( 25188341 ) Normalized brain volume ( 19010793 ) Platelet thrombus formation ( 22550155 ) Plateletcrit ( 32888494 )
Interacting Genes		3 interacting genes: SVIL YWHAG YWHAZ	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		10198	6840
HPRD ID		12022	04992
Ensembl ID		ENSG00000051825	ENSG00000197321
Uniprot IDs		Q99550	A0A6I8PIX7 O95425 Q569J5
PDB IDs		Not available	2K6M 2K6N
GO Terms Enriched among Interactors		None	Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process