ALYREF and MAGOH

Number of citations: 53 (PubMedID 11707413)
Data Source: HPRD (in vitro)

		ALYREF	MAGOH
Name		Aly/REF export factor	mago homolog, exon junction complex subunit
Structure
GO Annotations	Cellular Component	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding C5-methylcytidine-containing RNA Reader Activity	RNA Binding Protein Binding
	Biological Process	Osteoblast Differentiation MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GWAS		No GWAS studies recorded	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		13 interacting genes: AKT1 CEBPA DDX39B ESR1 FOXP1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A	22 interacting genes: ALYREF CEP70 CORO1A CPSF7 DPH2 DPPA4 EIF4A3 FXR1 GOLGA2 IPO13 MAP1B NXF1 PPP1R16B PTBP2 RBM8A TADA2A TFIP11 UPF3B XIST YWHAQ ZKSCAN8 ZRANB1
Entrez ID		10189	4116
HPRD ID		09168	04005
Ensembl ID		ENSG00000183684	ENSG00000162385
Uniprot IDs		E9PB61 Q86V81	P61326
PDB IDs		3ULH 7ZNJ 7ZNK	1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
GO Terms Enriched among Interactors		Nucleoplasm MRNA Transport RNA Transport Transcription Export Complex MRNA Export From Nucleus RNA Export From Nucleus Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Cell Development Positive Regulation Of Cell Population Proliferation RNA Metabolic Process Nuclear Export Osteoblast Differentiation Mononuclear Cell Differentiation T Cell Differentiation Leukocyte Differentiation Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Gene Expression Nitric-oxide Synthase Regulator Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Animal Organ Development Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Transcription Regulator Complex Lymphocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Organ Growth Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Tumor Necrosis Factor Myelin Maintenance Nucleus T Cell Activation Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Osteoblast Development Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Factor Activity	MRNA Binding MRNA Transport Exon-exon Junction Complex Nucleic Acid Binding RNA Transport Nucleobase-containing Compound Transport MRNA Export From Nucleus Spliceosomal Complex RNA Export From Nucleus Catalytic Step 2 Spliceosome MRNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Nuclear Speck Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Nuclear Export Cellular Localization RNA Binding Intracellular Transport Neuronal Cell Body RNA Splicing U2-type Catalytic Step 1 Spliceosome Transcription Export Complex Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleus Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell MRNA Catabolic Process RNA Processing Regulation Of MRNA Metabolic Process Induction Of Synaptic Plasticity By Chemical Substance Ribonucleoprotein Complex Binding Positive Regulation Of Translation Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion RNA Metabolic Process Regulation Of RNA Splicing Regulation Of Translation RNA Catabolic Process Organelle Assembly MRNA Splicing, Via Spliceosome 2-(3-amino-3-carboxypropyl)histidine Synthase Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Uropod Organization Spliceosomal Complex Disassembly RNA Splicing, Via Transesterification Reactions Dendrite