CDH16 and G6PC1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CDH16	G6PC1
Name		cadherin 16	glucose-6-phosphatase catalytic subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Glucose-6-phosphatase Activity Protein Binding Phosphotransferase Activity, Alcohol Group As Acceptor Hydrolase Activity Phosphate Ion Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion	Glycogen Metabolic Process Glycogen Catabolic Process Gluconeogenesis Triglyceride Metabolic Process Steroid Metabolic Process Response To Carbohydrate Regulation Of Gene Expression Glucose-6-phosphate Transport Response To Nutrient Levels Response To Food Response To Insulin Cellular Response To Insulin Stimulus Multicellular Organism Growth Glucose Homeostasis Cholesterol Homeostasis Urate Metabolic Process Chemical Homeostasis Glucose 6-phosphate Metabolic Process Lipid Homeostasis Response To Caloric Restriction Response To Resveratrol
Pathways		None	Glycogen storage disease type Ia (G6PC) Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Diseases		None	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: CTNNB1 G6PC1	4 interacting genes: CDH16 FOXO1 NSL1 SNX13
Entrez ID		1014	2538
HPRD ID		11929	01983
Ensembl ID		ENSG00000166589	ENSG00000131482
Uniprot IDs		O75309	P35575
PDB IDs		Not available	9J7U 9J7V
GO Terms Enriched among Interactors		Response To Caloric Restriction Transmembrane Transporter Binding Catenin Complex Homeostatic Process Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Endothelial Cell Differentiation Cell Periphery Cell-cell Junction Assembly Protein Phosphatase Binding Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Bicellular Tight Junction Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex NADH Dehydrogenase (quinone) (non-electrogenic) Activity NADPH Dehydrogenase (quinone) Activity NAD(P)H Dehydrogenase (quinone) Activity Response To Resveratrol Glucose-6-phosphatase Activity Astrocyte Fate Commitment	None