RBM12 and TBC1D4

Number of citations: 39 (PubMedID 12421765)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		RBM12	TBC1D4
Name		RNA binding motif protein 12	TBC1 domain family member 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ribonucleoprotein Complex	Cytoplasm Golgi Apparatus Cytosol Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of RNA Splicing	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GWAS		Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Diabetic retinopathy ( 23562823 ) Eosinophil count ( 32888494 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heart failure ( 20445134 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 27863252 32888494 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Red blood cell count ( 29403010 32888494 27863252 ) Serum alkaline phosphatase levels ( 33547301 ) Two-hour glucose ( 25043022 ) Type 2 diabetes ( 29926116 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Interacting Genes		8 interacting genes: BRAP GIGYF2 OPTN PRMT2 RBFOX2 RBM10 SNRPB TBC1D4	16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		10137	9882
HPRD ID		06212	18164
Ensembl ID		ENSG00000244462	ENSG00000136111
Uniprot IDs		Q9NTZ6	O60343
PDB IDs		1WEL 2CPY 2DNN 2EK1 2EK6	3QYB 7NIX
GO Terms Enriched among Interactors		Negative Regulation Of Cell Cycle G1/S Phase Transition Protein Methylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3R8 Methyltransferase Activity RNA Splicing Regulation Of MRNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Progesterone Receptor Binding MRNA Processing U2 SnRNP Binding Macromolecule Methylation Regulation Of MRNA Splicing, Via Spliceosome SnRNP Binding Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Nucleoplasm Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Methylation Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling MRNA Splicing, Via Spliceosome RNA Binding U7 SnRNP Histone Pre-mRNA DCP Binding 7-methylguanosine Cap Hypermethylation Histone Pre-mRNA 3'end Processing Complex MRNA Metabolic Process U1 SnRNP Binding Regulation Of RNA Splicing Regulation Of Ribosome Biogenesis Regulation Of MRNA Stability Regulation Of MRNA Processing Negative Regulation Of Ribosome Biogenesis Nucleic Acid Binding Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vesicle Fusion Vesicle Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Type 2 Mitophagy Proximal Dendrite Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle	Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction