RBM12 and GIGYF2

Number of citations: 0 (PubMedID 16120600)
Data Source: HPRD (two hybrid)

		RBM12	GIGYF2
Name		RNA binding motif protein 12	GRB10 interacting GYF protein 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ribonucleoprotein Complex	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Regulation Of RNA Splicing	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome
Diseases		None	Parkinson's disease (PD)
GWAS		Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Anxiety and stress-related disorders ( 31116379 ) Appendicular lean mass ( 33097823 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Coronary artery disease ( 29212778 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Hip circumference adjusted for BMI ( 34021172 ) Myocardial infarction ( 33532862 ) Schizophrenia ( 23974872 25056061 29483656 )
Interacting Genes		8 interacting genes: BRAP GIGYF2 OPTN PRMT2 RBFOX2 RBM10 SNRPB TBC1D4	12 interacting genes: APC CNOT9 CRYAA GRB10 GRB14 GRB7 RBM12 RNF10 SNRPB UBC USP7 WBP11
Entrez ID		10137	26058
HPRD ID		06212	11639
Ensembl ID		ENSG00000244462	ENSG00000204120
Uniprot IDs		Q9NTZ6	Q6Y7W6
PDB IDs		1WEL 2CPY 2DNN 2EK1 2EK6	5NVL 5NVM 7RUP
GO Terms Enriched among Interactors		Negative Regulation Of Cell Cycle G1/S Phase Transition Protein Methylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3R8 Methyltransferase Activity RNA Splicing Regulation Of MRNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Progesterone Receptor Binding MRNA Processing U2 SnRNP Binding Macromolecule Methylation Regulation Of MRNA Splicing, Via Spliceosome SnRNP Binding Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Nucleoplasm Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Methylation Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling MRNA Splicing, Via Spliceosome RNA Binding U7 SnRNP Histone Pre-mRNA DCP Binding 7-methylguanosine Cap Hypermethylation Histone Pre-mRNA 3'end Processing Complex MRNA Metabolic Process U1 SnRNP Binding Regulation Of RNA Splicing Regulation Of Ribosome Biogenesis Regulation Of MRNA Stability Regulation Of MRNA Processing Negative Regulation Of Ribosome Biogenesis Nucleic Acid Binding Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vesicle Fusion Vesicle Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Type 2 Mitophagy Proximal Dendrite Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle	Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation