ARPC4 and RNF130

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		ARPC4	RNF130
Name		actin related protein 2/3 complex subunit 4	ring finger protein 130
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Actin Cytoskeleton Site Of Double-strand Break Cell Projection Extracellular Exosome	Cytoplasm Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	None
GWAS		No GWAS studies recorded	LDL cholesterol ( 21347282 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Systolic blood pressure ( 30224653 )
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	14 interacting genes: ARPC4 EGFR FGFR3 PDCD1 SCN2A TGFBR1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z
Entrez ID		10093	55819
HPRD ID		10368	11504
Ensembl ID		ENSG00000241553	ENSG00000113269
Uniprot IDs		P59998	E5RI87 Q2HIY3 Q86XS8
PDB IDs		6UHC 6YW6 6YW7 8P94	Not available
GO Terms Enriched among Interactors		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Actin Filament Organization Actin Cytoskeleton Actin Binding Structural Constituent Of Cytoskeleton Supramolecular Fiber Organization Actin Filament Binding Site Of Double-strand Break Focal Adhesion Actin Polymerization-dependent Cell Motility Lamellipodium Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Chromosome Movement Towards Spindle Pole Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Cytoskeleton Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Spindle Localization Meiotic Cytokinesis Regulation Of Cell Projection Assembly Extracellular Exosome Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Asymmetric Cell Division Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Regulation Of Protein-containing Complex Assembly Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Cell Motility Growth Cone Leading Edge Tubulobulbar Complex Actin Polymerization Or Depolymerization Cell Leading Edge Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Type II Interferon Negative Regulation Of Membrane Tubulation	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Nucleotide Binding Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein K63-linked Ubiquitination Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Receptor Complex Regulation Of Protein Ubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Shc-EGFR Complex Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction