ARPC5 and ACTR2

Number of citations: 0 (PubMedID 11721045)
Data Source: HPRD (in vitro)

		ARPC5	ACTR2
Name		actin related protein 2/3 complex subunit 5	actin related protein 2
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Cortical Cytoskeleton Secretory Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
GWAS		No GWAS studies recorded	Calcific aortic valve stenosis ( 32141789 ) Coronary artery disease ( 29212778 33020668 ) Heel bone mineral density ( 30598549 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Metabolite levels ( 23823483 )
Interacting Genes		6 interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1	19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL
Entrez ID		10092	10097
HPRD ID		11969	05023
Ensembl ID		ENSG00000162704	ENSG00000138071
Uniprot IDs		O15511	P61160
PDB IDs		6UHC 6YW7	6UHC 6YW6 6YW7 8P94
GO Terms Enriched among Interactors		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Actin Filament Binding Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Actin Cytoskeleton Meiotic Cytokinesis Actin Binding Site Of Double-strand Break Asymmetric Cell Division Supramolecular Fiber Organization Cytoskeleton Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Extracellular Exosome Regulation Of Lamellipodium Organization Spindle Localization Cellular Response To Type II Interferon Focal Adhesion Nuclear Glucocorticoid Receptor Activity Cell Division Tubulobulbar Complex Chromosome Localization Cytoskeleton-dependent Cytokinesis Response To Type II Interferon Response To Cytokine Response To Peptide Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Cell Cycle Cytosol Establishment Or Maintenance Of Cell Polarity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Actin Cap Nuclear Receptor-mediated Corticosteroid Signaling Pathway Response To Lipid Steroid Hormone Binding Calcium-dependent Protein Serine/threonine Kinase Activity Response To Cortisol Macropinocytosis Actin Polymerization-dependent Cell Motility Nucleus Regulation Of Cell Projection Assembly Mammary Gland Duct Morphogenesis Microglia Differentiation Cilium Assembly Regulation Of Glucocorticoid Biosynthetic Process Cellular Response To Growth Factor Stimulus	Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity