TOM1 and HACL2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TOM1	HACL2
Name		target of myb1 membrane trafficking protein	2-hydroxyacyl-CoA lyase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Acetolactate Synthase Complex Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Clathrin Heavy Chain Binding Phosphatidylinositol Binding Ubiquitin Binding Myosin VI Binding	Magnesium Ion Binding Catalytic Activity Acetolactate Synthase Activity Protein Binding Lyase Activity Thiamine Pyrophosphate Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Endocytosis Signal Transduction Protein Transport Endosomal Transport Substrate Localization To Autophagosome Autophagosome-lysosome Fusion Positive Regulation Of Autophagosome Maturation Regulation Of Endosome Organization	Fatty Acid Alpha-oxidation Lipid Metabolic Process Fatty Acid Metabolic Process
Pathways		Neutrophil degranulation	None
GWAS		Cholesterol, total ( 24097068 ) HDL cholesterol ( 29404214 ) High density lipoprotein cholesterol levels ( 31217584 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Hippocampal volume in mild cognitive impairment ( 29274321 ) Inflammatory bowel disease ( 28067908 ) Low density lipoprotein cholesterol levels ( 32154731 ) Multiple myeloma ( 26007630 ) Multiple myeloma and monoclonal gammopathy ( 26007630 ) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 34074324 ) Ulcerative colitis ( 28067908 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: APP BBS4 BBS5 BBS9 CLTC DAZAP2 EEA1 HACL2 LITAF LRRC20 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SNCA SSBP2 TOLLIP UBC UBE2D1 WWP2 ZFYVE16 ZNF512B	5 interacting genes: ATXN1 CEP76 ECT2 TOM1 XRCC6
Entrez ID		10043	10994
HPRD ID		05265	16152
Ensembl ID		ENSG00000100284	ENSG00000105135
Uniprot IDs		B3KUF5 O60784	A1L0T0 M0R026
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56	Not available
GO Terms Enriched among Interactors		BBSome Protein-containing Complex Protein Localization To Vacuole Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Organelle Centriolar Satellite Establishment Of Localization In Cell Protein Targeting To Vacuole Ciliary Membrane Protein Localization To Lysosome Potassium Channel Inhibitor Activity Establishment Of Protein Localization To Vacuole Cytosol Intracellular Protein Localization Protein Transport Receptor Internalization Modification-dependent Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane 1-phosphatidylinositol Binding Early Endosome Membrane Intracellular Transport Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Establishment Of Melanosome Localization Pericentriolar Material Melanosome Localization Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Vesicle Localization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity WW Domain Binding Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Regulation Of Monoatomic Cation Transmembrane Transport Pigment Granule Localization Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion	Centralspindlin Complex Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Chemical Stress Positive Regulation Of Cell Differentiation Regulation Of Organelle Organization Positive Regulation Of Protein Phosphorylation Cytosol Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress Protein-containing Complex DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Poly(G) Binding POZ Domain Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Clathrin Heavy Chain Binding Substrate Localization To Autophagosome Myosin VI Binding Regulation Of Endosome Organization Positive Regulation Of Autophagosome Maturation Nuclear Inclusion Body Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Positive Regulation Of Developmental Process Autophagosome-lysosome Fusion Regulation Of Autophagosome Maturation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cellular Hyperosmotic Response