FRAT1 and LMAN2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		FRAT1	LMAN2
Name		FRAT regulator of Wnt signaling pathway 1	lectin, mannose binding 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cell Surface Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Protein Binding Molecular Function Inhibitor Activity	Protein Binding D-mannose Binding Carbohydrate Binding Heat Shock Protein Binding Metal Ion Binding
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Phagocytosis
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	COPII-mediated vesicle transport Cargo concentration in the ER
GWAS		Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte count ( 32888494 ) White blood cell count ( 32888494 )	Activated partial thromboplastin time ( 22703881 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Blood protein levels ( 30072576 ) Chronic kidney disease ( 20383146 ) High light scatter reticulocyte count ( 32888494 ) Red blood cell count ( 27863252 ) Reticulocyte count ( 32888494 ) Serum uric acid levels ( 30993211 ) Triglyceride levels ( 32203549 ) Urinary calcium excretion ( 31993563 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	4 interacting genes: ATP13A2 FRAT1 MAPK9 SUPT5H
Entrez ID		10023	10960
HPRD ID		03935	17285
Ensembl ID		ENSG00000165879	ENSG00000169223
Uniprot IDs		Q92837	A0A384NPY7 Q12907
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4	Not available
GO Terms Enriched among Interactors		Wnt Signalosome	Regulation Of Protein Catabolic Process JUN Kinase Activity Protein Localization To Tricellular Tight Junction DSIF Complex Regulation Of Intracellular Protein Transport Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Cellular Response To Oxidative Stress Regulation Of Macroautophagy Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Polyamine Transmembrane Transport Cellular Response To Chemical Stress Regulation Of Intracellular Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Positive Regulation Of Podosome Assembly ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Inflammatory Response To Wounding Response To Metal Ion Regulation Of Podosome Assembly Response To Manganese Ion Autophagosome-lysosome Fusion MAP Kinase Activity Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Autophagy Positive Regulation Of Exosomal Secretion Enzyme Binding Protein Localization To Cell-cell Junction Regulation Of Exosomal Secretion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Protein Transport Cellular Response To Zinc Ion