FRAT1 and LAMC3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		FRAT1	LAMC3
Name		FRAT regulator of Wnt signaling pathway 1	laminin subunit gamma 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Basement Membrane Membrane Extracellular Matrix
	Molecular Function	Protein Binding Molecular Function Inhibitor Activity	Structural Molecule Activity
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Cell Morphogenesis Cell Adhesion Visual Perception Astrocyte Development Retina Development In Camera-type Eye
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
GWAS		Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte count ( 32888494 ) White blood cell count ( 32888494 )	Alcohol consumption (max-drinks) ( 29460428 ) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195 ) Degraded stimulus continuous performance test score ( 31596458 ) Endometriosis ( 28333195 ) Oral cavity and pharyngeal cancer ( 27749845 ) Oral cavity cancer ( 27749845 ) Smoking status (heavy vs never) ( 26423011 )
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		10023	10319
HPRD ID		03935	05069
Ensembl ID		ENSG00000165879	ENSG00000050555
Uniprot IDs		Q92837	Q8N2D6 Q9Y6N6
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4	Not available
GO Terms Enriched among Interactors		Wnt Signalosome	Acute-phase Response Blood Microparticle Acute Inflammatory Response Response To Bacterium Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage