NAT2 and NAA10

Number of citations: 0 (PubMedID 12888564)
Data Source: HPRD (in vitro)

		NAT2	NAA10
Name		N-acetyltransferase 2	N-alpha-acetyltransferase 10, NatA catalytic subunit
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Membrane NatA Complex
	Molecular Function	Arylamine N-acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity N-hydroxyarylamine O-acetyltransferase Activity	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Protein-N-terminal-alanine Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Ribosome Binding Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process	Protein Acetylation N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Acetylation Paracetamol ADME	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Bladder cancer ( 20972438 24163127 ) Cholesterol, total ( 20686565 24097068 ) Coronary artery disease ( 29212778 33020668 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Insulin resistance/response ( 25798622 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Iron status biomarkers (transferrin levels) ( 25352340 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Liver injury in anti-tuberculosis drug treatment ( 31109976 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 31589552 ) Metabolic traits ( 21886157 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Paclitaxel-induced neuropathy ( 23776197 ) Serum metabolite levels ( 33031748 ) Total cholesterol levels ( 28334899 33339817 ) Triglyceride levels ( 29403010 32203549 33339817 30698716 28334899 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 20686565 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites ( 26352407 21572414 ) Urinary metabolites (H-NMR features) ( 24586186 ) Youthful appearance (self-reported) ( 32339537 )	Systemic lupus erythematosus ( 26502338 )
Interacting Genes		17 interacting genes: APC APP AURKA BAG4 CDKN2A CDKN2C ERBB2 FZR1 HMMR IGF1R MBD4 NAA10 NBN PALB2 PPM1D STK11 WT1	59 interacting genes: ACOT12 BAALC BCOR CALCOCO2 CASP8AP2 CCDC106 CCDC174 CDC25A CEBPA CEP44 CFTR CREB3 CREBRF CTNNB1 DDIT4L DHX57 EHMT2 FIP1L1 GPATCH2L H4C1 HIF1A HIF1AN HSPA4 HYPK KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 MCRS1 MDM4 MEOX2 MKRN1 MRPS11 NAA15 NAA16 NAA50 NAT1 NAT2 NOXA1 PDE4DIP PGK1 PLSCR3 PPP2R3B PSME2 RAB3IP RBCK1 RCN3 RIMBP2 RPL26 SEMA3B SNX33 SSX2IP TAF7L TSEN54 UBC ZBTB14 ZNF202 ZNF655
Entrez ID		10	8260
HPRD ID		02000	02056
Ensembl ID		ENSG00000156006	ENSG00000102030
Uniprot IDs		A4Z6T7 A9X7Q9 P11245	B7Z9N2 P41227
PDB IDs		2PFR	6C95 6C9M 6PPL 6PW9 9F1B 9F1C 9F1D 9FPZ 9FQ0
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Nucleus Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Modification Process Positive Regulation Of Catabolic Process Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Apoptotic Process Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Growth Negative Regulation Of Cell Cycle Negative Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Developmental Growth Regulation Of Proteolysis Protein Localization To Organelle Regulation Of Reproductive Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Positive Regulation Of Proteolysis Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Growth Negative Regulation Of Chromosome Organization Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity	Acetyltransferase Activity NatA Complex Cytosol N-terminal Protein Amino Acid Acetylation Protein Binding Arylamine N-acetyltransferase Activity Nucleus Protein Acetylation