TNFRSF8

Name	TNF receptor superfamily member 8
Structure
Novel Interactors	7 novel interactors: CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 WRAP73
Interactors	7 interactors: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways	TNFs bind their physiological receptors
Drugs	Iratumumab XmAb 2513 Brentuximab vedotin
GWAS	Asthma ( 31959851 32296059 34103634 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Sum eosinophil basophil counts ( 27863252 ) Tuberculosis ( 29036319 )
Entrez ID	943
HPRD ID	01074
Ensembl ID	ENSG00000120949
Uniprot IDs	A5D8T4 P28908
PDB IDs	1D01
GO Terms Enriched among Interactors ?	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation