P4HA2

Description		prolyl 4-hydroxylase subunit alpha 2
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Proline
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		2 novel interacting genes: CD86 PRKAR2A
Interacting Genes		7 interacting genes: CLNK CREB3 FHL3 OGT P4HB PRRC2A TNS4
Entrez ID		8974
HPRD ID		11862
Ensembl ID		ENSG00000072682
Uniprot IDs		O15460 Q05DA4
PDB IDs		6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC
Enriched GO Terms of Interacting Partners?		Focal Adhesion
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