SUCLA2

Name	succinate-CoA ligase ADP-forming subunit beta
Structure
Interactors	11 interactors: AGTRAP ALAS2 ARL6IP1 CMTM5 FAM9B FKBP7 MAGEA11 MAL2 MTNR1A SEC23A TNFRSF10D
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Pathway Succinyl-CoA Catabolic Process
Pathways	Citric acid cycle (TCA cycle)
Diseases	Mitochondrial DNA depletion syndrome (MDS)
GWAS	Aging (time to event) ( 21782286 ) Colorectal cancer (diet interaction) ( 24743840 ) Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) Serum metabolite levels ( 33031748 ) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385 ) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122 ) Visceral adipose tissue adjusted for BMI ( 22589738 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 )
Entrez ID	8803
HPRD ID	06798
Ensembl ID	ENSG00000136143
Uniprot IDs	E5KS60 Q9P2R7
PDB IDs	6G4Q