TNFSF10

Name	TNF superfamily member 10
Structure
Interactors	10 interactors: ACP5 CASP3 CFTR RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding TRAIL Binding Metal Ion Binding
	Biological Process	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Signaling TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
GWAS	Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Breast cancer ( 28171663 ) Breast cancer (estrogen-receptor negative) ( 28171663 ) Carotid plaque burden ( 28282560 ) Cocaine dependence ( 31212010 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Liver volume ( 34128465 ) Monocyte percentage of white cells ( 27863252 ) TRAIL levels ( 27989323 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 )
Entrez ID	8743
HPRD ID	04670
Ensembl ID	ENSG00000121858
Uniprot IDs	P50591 Q6IBA9
PDB IDs	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
GO Terms Enriched among Interactors ?	TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Apoptotic Process Programmed Cell Death Activation Of NF-kappaB-inducing Kinase Activity Cell Surface Apoptotic Signaling Pathway Golgi-associated Vesicle Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity Signaling Receptor Activity Negative Regulation Of Superoxide Anion Generation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRAIL Receptor Activity Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Phospholipase A2 Activator Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protease Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Monoatomic Anion Transport Multicellular Organismal-level Homeostasis Anterior Neural Tube Closure Cellular Response To Staurosporine Positive Regulation Of Enamel Mineralization Positive Regulation Of Protein Kinase Activity Luteolysis Glial Cell Apoptotic Process Transepithelial Water Transport Positive Regulation Of Kinase Activity Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Immune System Process Acid Phosphatase Activity Response To Anesthetic Positive Regulation Of Tooth Mineralization Protein-cysteine S-stearoyltransferase Activity Ferric Iron Binding Death-inducing Signaling Complex