UNG

Name	uracil DNA glycosylase
Structure
Novel Interactors	10 novel interactors: ATP2A2 CCDC33 CRY1 DAO FTH1 KERA P2RY6 PRDM4 RPS20 SLC17A7
Interactors	6 interactors: APP CAPN11 CEBPA PCNA RPA2 SEZ6L2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Drugs	4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases	Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS	Feeling miserable ( 29500382 ) Feeling worry ( 29500382 ) Neurociticism ( 29500382 ) Worry too long after an embarrassing experience ( 29500382 )
Entrez ID	7374
HPRD ID	01881
Ensembl ID	ENSG00000076248
Uniprot IDs	E5KTA5 E5KTA6 P13051
PDB IDs	1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C
GO Terms Enriched among Interactors ?	Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity