UCN

Name	urocortin
Structure
Novel Interactors	1 novel interactors: RAB18
Interactors	4 interactors: CRHBP CRHR1 CRHR2 LEP
GO Annotations	Cellular Component	Extracellular Region Axon Dendrite Neuronal Cell Body Varicosity Perikaryon Axon Terminus
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Startle Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Learning Or Memory Feeding Behavior Associative Learning Aerobic Respiration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Auditory Stimulus Positive Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Social Behavior Vasodilation Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Calcium Ion Import Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways	Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin
GWAS	Crohn's disease ( 23128233 )
Entrez ID	7349
HPRD ID	02970
Ensembl ID	ENSG00000163794
Uniprot IDs	P55089
PDB IDs	2RMF 3N96 6PB0 6PB1 7TRY 7TS0
GO Terms Enriched among Interactors ?	Cellular Response To Peptide Hormone Stimulus Corticotropin-releasing Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Corticotropin-releasing Hormone Stimulus Female Pregnancy Behavioral Response To Ethanol Hormone-mediated Signaling Pathway Adult Behavior Response To Hormone Cellular Response To Oxygen-containing Compound Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Peptide Secretion Axon Terminus Secretion By Cell Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Peptide Hormone Secretion Peptide Secretion Negative Regulation Of Corticotropin Secretion Secretion Regulation Of Transmembrane Transporter Activity Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Secondary Lysosome Regulation Of Hormone Levels Regulation Of Monoatomic Ion Transmembrane Transporter Activity Hormone Secretion Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Negative Regulation Of Glutamine Transport Peptide Transport Regulation Of System Process Regulation Of Secretion By Cell Hormone Transport Response To Estradiol Negative Regulation Of Transmembrane Transport Regulation Of Secretion Corticotropin Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Fat Cell Apoptotic Process Amide Transport Negative Regulation Of Secretion By Cell Negative Regulation Of Glucagon Secretion Signal Release Signal Transduction Negative Regulation Of Secretion