SRMS

Name	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Structure	No pdb structure
Interactors	5 interactors: DUXAP9 NCK2 NEDD4 NEDD4L SKAP2
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Protein Deubiquitination Peptidyl-tyrosine Phosphorylation Cell Differentiation Cellular Response To Nutrient Levels Peptidyl-tyrosine Autophosphorylation TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways	PTK6 Down-Regulation
Drugs	Fostamatinib
GWAS	Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Prostate cancer ( 23535732 )
Entrez ID	6725
HPRD ID	10250
Ensembl ID	ENSG00000125508
Uniprot IDs	Q9H3Y6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development Receptor Metabolic Process Protein Monoubiquitination Receptor Internalization Regulation Of Dendrite Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Lymphocyte Activation Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Formation Of Structure Involved In A Symbiotic Process Regulation Of Dendrite Development Leukocyte Activation Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Cell Activation Channel Inhibitor Activity Transmembrane Transporter Binding Phosphothreonine Residue Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Protein Metabolic Process Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Sodium Ion Transport Receptor-mediated Endocytosis Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Caveolin-mediated Endocytosis Plasma Membrane Bounded Cell Projection Organization Nuclear Receptor-mediated Corticosteroid Signaling Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Ubiquitin-protein Transferase Activity Synapse Organization Positive Regulation Of Translation In Response To Stress Regulation Of Caveolin-mediated Endocytosis Cell Projection Organization Regulation Of Monoatomic Cation Transmembrane Transport Signal Complex Assembly Protein Polyubiquitination Negative Regulation Of Sodium Ion Transmembrane Transport