BOK

Name	BCL2 family apoptosis regulator BOK
Structure
Interactors	3 interactors: BCL2A1 MCL1 NOA1
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Early Endosome Membrane Mitochondrial Membrane Trans-Golgi Network Membrane Cis-Golgi Network Membrane Recycling Endosome Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Channel Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity BH Domain Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Protein Complex Oligomerization Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Transmembrane Transport Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Cisplatin Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
GWAS	Appendicular lean mass ( 33097823 ) Brain structure ( 20171287 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Planum temporale asymmetry index ( 31887566 ) Prostate cancer ( 23535732 ) Thyroid stimulating hormone levels ( 32769997 )
Entrez ID	666
HPRD ID	05657
Ensembl ID	ENSG00000176720
Uniprot IDs	A0A024R4A8 A0A481T0W6 A0A4D6NU76 Q9UMX3
PDB IDs	6CKV
GO Terms Enriched among Interactors ?	Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Process Organelle Fusion Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane BH Domain Binding Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway BH3 Domain Binding Matrix Side Of Mitochondrial Inner Membrane Mitochondrial Ribosome Assembly Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Organelle Organization Negative Regulation Of Anoikis Ribosome Assembly Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Anoikis Protein Transmembrane Transporter Activity DNA Damage Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Cell Fate Determination Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transmembrane Transport Positive Regulation Of Neuron Apoptotic Process Protein Transmembrane Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway