OPN1LW

Name	opsin 1, long wave sensitive
Structure
Novel Interactors	1 novel interactors: TAFAZZIN
Interactors	6 interactors: NCOA2 NRM PIAS3 RANBP2 TICAM2 TRARG1
GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Absorption Of Visible Light Positive Regulation Of Cytokinesis Cellular Response To Light Stimulus
Pathways	The retinoid cycle in cones (daylight vision) G alpha (i) signalling events Opsins Defective visual phototransduction due to OPN1LW loss of function
Diseases	Blue cone monochromacy Colorblindness, including: Dichromacy; Anomalous trichromacy
GWAS	Lymphocyte count ( 32888494 )
Entrez ID	5956
HPRD ID	02366
Ensembl ID	ENSG00000102076
Uniprot IDs	P04000
PDB IDs	8IU2
GO Terms Enriched among Interactors ?	SUMO Ligase Activity SUMO Transferase Activity Toll-like Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Protein Sumoylation Innate Immune Response-activating Signaling Pathway Annulate Lamellae Negative Regulation Of Immune System Process Cytoplasmic Periphery Of The Nuclear Pore Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Regulation Of Glucose Metabolic Process Nuclear Pore Cytoplasmic Filaments Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Cardiolipin Metabolic Process Transcription Coregulator Activity Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Glucose Import In Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production TRAM-dependent Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Nuclear Envelope RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Intracellular Receptor Signaling Pathway Nuclear Pore Nuclear Basket Nuclear Inclusion Body Kinase Activator Activity Nuclear Membrane Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Endosome To Plasma Membrane Protein Transport Vesicle Fusion To Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway