UGT1A1

Name	UDP glucuronosyltransferase family 1 member A1
Structure	No pdb structure
Novel Interactors	1 novel interactors: AGAP1
Interactors	3 interactors: COPZ1 SEC23B UGDH
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Steroid Metabolic Process Flavone Metabolic Process
Pathways	Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia Aspirin ADME Paracetamol ADME
Drugs	Fostamatinib
Diseases	Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS	Bilirubin levels ( 19419973 20639394 22085899 31801373 23371916 19414484 ) Bilirubin levels in extreme obesity ( 25246029 ) Cholelithiasis-related traits in sickle cell anemia ( 22558097 ) Cholesterol, total ( 24097068 ) Circulating cell-free DNA ( 22511988 ) Hair greying ( 26926045 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 ) Low density lipoprotein cholesterol levels ( 32154731 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Serum metabolite levels ( 23093944 ) Total bilirubin levels ( 29403010 34117260 ) Total bilirubin levels in HIV-1 infection ( 25884002 )
Entrez ID	54658
HPRD ID	08933
Ensembl ID	ENSG00000241635
Uniprot IDs	P22309 Q5DT03
PDB IDs	Not available
GO Terms Enriched among Interactors ?	UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity UDP-glucuronate Metabolic Process COPII-coated Vesicle Budding Protein Transport GTPase Activator Activity Establishment Of Protein Localization Golgi Vesicle Transport Postsynaptic Endosome Heparan Sulfate Proteoglycan Biosynthetic Process Gastrulation With Mouth Forming Second Protein Hexamerization Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Biosynthetic Process Intracellular Protein Localization COPII Vesicle Coat COPII-coated Vesicle Cargo Loading COPI-coated Vesicle Membrane COPI Vesicle Coat Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Chondroitin Sulfate Proteoglycan Metabolic Process Intracellular Protein Transport Nucleotide-sugar Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Membrane Coat NAD Binding Vesicle Budding From Membrane Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Proteoglycan Biosynthetic Process Cytoplasmic Vesicle ER To Golgi Transport Vesicle Membrane