DACT1

Description		dishevelled binding antagonist of beta catenin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex Synapse
	Molecular Function	Protein Kinase C Binding Protein Binding Beta-catenin Binding Histone Deacetylase Binding Protein Kinase A Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Delta-catenin Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Embryonic Hindgut Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nodal Signaling Pathway Negative Regulation Of Beta-catenin-TCF Complex Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Colorectal cancer or advanced adenoma ( 30510241) Dentate gyrus granule cell layer volume (corrected for total hippocampal volume) ( 30279459) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Language functional connectivity ( 34929384) Left–right brain asymmetry ( 33723403) Metabolite levels ( 23823483) Occipital lobe volume ( 31396565) Parietal lobe volume ( 31396565)
Novel Interacting Genes		1 novel interacting genes: KIAA0586
Interacting Genes		7 interacting genes: APPL1 C7orf25 CSNK2B GRSF1 PPP1CC SH3GL2 TK1
Entrez ID		51339
HPRD ID		09709
Ensembl ID		ENSG00000165617
Uniprot IDs		Q9NYF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Adiponectin-activated Signaling Pathway
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