MTR

Name	5-methyltetrahydrofolate-homocysteine methyltransferase
Structure
Interactors	2 interactors: CDKN2A DYNLL1
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Methionine Synthase Activity Transferase Activity Cobalamin Binding Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Nervous System Development Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Axon Regeneration Methylation Pteridine-containing Compound Metabolic Process Tetrahydrofolate Metabolic Process Response To Axon Injury Homocysteine Metabolic Process L-methionine Salvage Cellular Response To Nitric Oxide
Pathways	Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG RHOH GTPase cycle Cobalamin (Cbl) metabolism
Drugs	Cyanocobalamin Tetrahydrofolic acid Methionine Hydroxocobalamin Mecobalamin Thimerosal
Diseases	Spina bifida
GWAS	Hallux valgus ( 32131869 ) Homocysteine levels ( 23824729 )
Entrez ID	4548
HPRD ID	01136
Ensembl ID	ENSG00000116984
Uniprot IDs	A0A7P0TAJ0 Q99707
PDB IDs	2O2K 4CCZ
GO Terms Enriched among Interactors ?	Ligase Inhibitor Activity Negative Regulation Of Phosphorylation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Regulation Of Intracellular Transport Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Localization Mitochondrial Depolarization Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Protein Neddylation Positive Regulation Of Apoptotic Process Involved In Development Ubiquitin-protein Transferase Inhibitor Activity Somatic Stem Cell Division Regulation Of Establishment Of Protein Localization Negative Regulation Of Immature T Cell Proliferation Protein Localization To Nucleolus Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Phosphorylation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Regulation Of Protein Transport Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Negative Regulation Of DNA-templated DNA Replication MDM2/MDM4 Family Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Ubiquitin Ligase Inhibitor Activity Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Intraciliary Retrograde Transport Replicative Senescence Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mammary Gland Epithelial Cell Proliferation Negative Regulation Of B Cell Proliferation