MMP3

Name	matrix metallopeptidase 3
Structure
Interactors	19 interactors: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 MMP14 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Innate Immune Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Cellular Response To Nitric Oxide Regulation Of Neuroinflammatory Response Response To Amyloid-beta Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs	Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 4-methoxybenzenesulfinate 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
GWAS	Alzheimer's disease ( 22832961 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Peripheral artery disease ( 31285632 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 )
Entrez ID	4314
HPRD ID	01703
Ensembl ID	ENSG00000149968
Uniprot IDs	P08254
PDB IDs	1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1 6MAV 6N9D 7S7L 7S7M
GO Terms Enriched among Interactors ?	Extracellular Space Extracellular Region Extracellular Matrix Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Metalloendopeptidase Inhibitor Activity Cytokine Activity Eosinophil Chemotaxis Eosinophil Migration CCR Chemokine Receptor Binding Extracellular Matrix Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Perineuronal Net Leukocyte Migration Chemokine Activity Myeloid Leukocyte Migration Extracellular Matrix Structural Constituent Conferring Compression Resistance Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Migration Chemokine-mediated Signaling Pathway Positive Regulation Of Cell Motility Hyaluronic Acid Binding Monocyte Chemotaxis Positive Regulation Of Locomotion Cell Migration Cell Chemotaxis Granulocyte Migration Positive Regulation Of Mononuclear Cell Migration Regulation Of Leukocyte Migration Golgi Lumen Mononuclear Cell Migration Peptidase Inhibitor Activity CCR2 Chemokine Receptor Binding Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Mononuclear Cell Migration Astrocyte Cell Migration Negative Regulation Of Proteolysis Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Antimicrobial Humoral Response Locomotion Enzyme Inhibitor Activity Skeletal System Development