MAN2A1

Name	mannosidase alpha class 2A member 1
Structure	No pdb structure
Novel Interactors	2 novel interactors: APC EPB41L4A-AS1
Interactors	1 interactors: SEC23B
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Liver Development Carbohydrate Metabolic Process Mannose Metabolic Process Protein Glycosylation N-glycan Processing Mitochondrion Organization Vacuole Organization Respiratory Gaseous Exchange By Respiratory System Viral Protein Processing Lung Alveolus Development Positive Regulation Of Neurogenesis Retina Morphogenesis In Camera-type Eye
Pathways	Intra-Golgi traffic Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs	Tridolgosir 2-deoxy-2-fluoro-alpha-D-mannosyl fluoride Ghavamiol Kifunensine 5-fluoro-beta-L-gulosyl fluoride 5-Thio-a/B-D-Mannopyranosylamine 1-deoxymannojirimycin (1R,2R,3R,4S,5R)-4-(Benzylamino)-5-(methylthio)cyclopentane-1,2,3-triol (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol
GWAS	Alzheimer's disease (cognitive decline) ( 23535033 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244 ) Exploratory eye movement dysfunction in schizophrenia (number of eye fixations) ( 26242244 ) Exploratory eye movement dysfunction in schizophrenia (responsive search score) ( 26242244 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels in HIV infection ( 33109212 ) Intelligence (MTAG) ( 29326435 ) Number of sexual partners ( 30643258 ) Schizophrenia ( 25056061 28991256 29483656 30285260 ) Triglyceride levels ( 34074324 )
Entrez ID	4124
HPRD ID	01110
Ensembl ID	ENSG00000112893
Uniprot IDs	Q16706
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Wnt Signalosome Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Microtubule Depolymerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Protein Kinase Regulator Activity Heart Valve Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Beta-catenin Destruction Complex Negative Regulation Of Cyclin-dependent Protein Kinase Activity Perinuclear Region Of Cytoplasm Catenin Complex Dynein Complex Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Endocardial Cushion Morphogenesis Gamma-catenin Binding Microtubule Plus-end Binding Plasma Membrane Bounded Cell Projection Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Vesicle Budding From Membrane COPII-coated Vesicle Budding COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Regulation Of Microtubule Depolymerization Negative Regulation Of Mitotic Nuclear Division