NDUFS7

Name	NADH:ubiquinone oxidoreductase core subunit S7
Structure
Novel Interactors	1 novel interactors: DPCD
Interactors	3 interactors: ARRB2 ENO2 MT-ND1
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Neuronal Cell Body Respiratory Chain Complex I Synaptic Membrane
	Molecular Function	Protease Binding NADH Dehydrogenase Activity Monooxygenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Metal Ion Binding Quinone Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Electron Transport Coupled Proton Transport Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways	Respiratory electron transport Complex I biogenesis
Drugs	NADH
Diseases	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	No GWAS studies recorded
Entrez ID	374291
HPRD ID	03491
Ensembl ID	ENSG00000115286
Uniprot IDs	F5H5N1 O75251 Q6ZS38 Q7LD69
PDB IDs	5XTB 5XTD 5XTH 5XTI
GO Terms Enriched among Interactors ?	Angiotensin Receptor Binding Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission, Dopaminergic D1 Dopamine Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Response To Xenobiotic Stimulus Phosphopyruvate Hydratase Complex Purine Ribonucleotide Metabolic Process Phosphopyruvate Hydratase Activity ATP Metabolic Process Generation Of Precursor Metabolites And Energy Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Third Ventricle Development Positive Regulation Of Cardiac Muscle Cell Differentiation Protein Kinase B Binding Purine Nucleotide Metabolic Process Neuronal Cell Body NADH Dehydrogenase Activity Enzyme Binding G Protein-coupled Receptor Internalization Nucleotide Metabolic Process Lateral Ventricle Development Left/right Pattern Formation Positive Regulation Of Cardiocyte Differentiation