HADHA

Name	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Structure
Novel Interactors	1 novel interactors: NCOA1
Interactors	10 interactors: ABCF2 ATXN2L CD74 CEBPA HSD17B10 NR4A1 PIN1 PTEN UBC YWHAQ
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid
	Molecular Function	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity NAD+ Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Insulin Cardiolipin Acyl-chain Remodeling
Pathways	Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs	NADH
Diseases	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	No GWAS studies recorded
Entrez ID	3030
HPRD ID	02934
Ensembl ID	ENSG00000084754
Uniprot IDs	E9KL44 P40939
PDB IDs	5ZQZ 5ZRV 6DV2
GO Terms Enriched among Interactors ?	MHC Class II Protein Binding, Via Antigen Binding Groove Positive Regulation Of RNA Biosynthetic Process NOS2-CD74 Complex Protein Stabilization Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of DNA-templated Transcription Regulation Of Macrophage Activation Transcription Regulator Complex Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ubiquitin Ligase Activator Activity Cis-trans Isomerase Activity Negative Regulation Of Synaptic Vesicle Clustering Reproductive Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Endocytic Vesicle Membrane Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macrophage Migration Inhibitory Factor Binding Negative Regulation Of Cell Motility Protein-containing Complex Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex RNA Metabolic Process Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Labyrinthine Layer Morphogenesis Negative Regulation Of Locomotion Regulation Of Protein Stability Regulation Of Protein Phosphorylation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Cellular Component Assembly CHOP-C/EBP Complex