A1CF

Name	APOBEC1 complementation factor
Structure
Interactors	26 interactors: ACTMAP APOBEC1 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SPMIP6 SYNCRIP TNPO2 TRAF1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Enzyme-substrate Adaptor Activity
	Biological Process	MRNA Processing Embryo Implantation MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Protein Stabilization Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways	mRNA Editing: C to U Conversion Formation of the Editosome
GWAS	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 31451708 31152163 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Gamma glutamyl transferase levels ( 33339817 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Interferon alpha levels in systemic lupus erythematosus ( 25338677 ) LDL cholesterol ( 30275531 ) Low density lipoprotein cholesterol levels ( 32154731 ) Narcolepsy with cataplexy ( 25986216 ) Serum uric acid levels ( 30993211 ) Total cholesterol levels ( 30275531 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Urate levels ( 31578528 31985003 23263486 ) Urate levels in lean individuals ( 25811787 )
Entrez ID	29974
HPRD ID	10627
Ensembl ID	ENSG00000148584
Uniprot IDs	B4E1E3 F8W9F8 Q9NQ94
PDB IDs	2CPD
GO Terms Enriched among Interactors ?	Chromosomal 5-methylcytosine DNA Demethylation Pathway MRNA Editing Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Modification Manchette