GLDC

Name	glycine decarboxylase
Structure
Novel Interactors	2 novel interactors: DNAI1 IFNA1
Interactors	2 interactors: SIRT3 TLR10
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Oxidoreductase Activity Glycine Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Amino Acid Metabolic Process Glycine Metabolic Process Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Methylamine Response To Lipoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways	Glycine degradation
Drugs	Pyridoxal phosphate
Diseases	Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS	Alanine aminotransferase levels ( 33339817 33547301 ) Alanine transaminase levels ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Glycine levels ( 30837465 31070104 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Metabolite levels ( 23823483 ) Overall survival in osteosarcoma ( 29210060 ) Periodontal microbiota ( 22699663 ) Serum metabolite levels ( 33031748 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Entrez ID	2731
HPRD ID	01996
Ensembl ID	ENSG00000178445
Uniprot IDs	P23378
PDB IDs	6I33 6I34 6I35
GO Terms Enriched among Interactors ?	Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Toll-like Receptor 2 Binding Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Histone Deacetylase Activity, NAD-dependent Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cellular Respiration Positive Regulation Of Ceramide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Sphingolipid Biosynthetic Process Dynein Heavy Chain Binding Dynein Light Chain Binding Outer Dynein Arm Cellular Response To Bacterial Lipopeptide NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding Response To Bacterial Lipoprotein NAD+ Binding Regulation Of Oxidoreductase Activity Dynein Axonemal Particle Outer Dynein Arm Assembly Regulation Of Membrane Lipid Metabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Phosphorylation Cytokine Receptor Binding Macromolecule Deacylation Glial Cell Projection NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Aerobic Respiration Positive Regulation Of Amide Metabolic Process 9+2 Motile Cilium Innate Immune Response Dynein Complex Axonemal Dynein Complex Assembly Response To Exogenous DsRNA Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Reactive Oxygen Species Metabolic Process