SNX5

Name	sorting nexin 5
Structure
Interactors	21 interactors: APPBP2 AQP2 BANP CDC37 CLTC CLTCL1 DNAJB11 DSCR9 FANCA HGS HMOX2 ITSN1 LAMTOR5 MESD MIB1 NRP1 OGT PFDN1 PRKRA PSMB8 RIGI
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Brush Border Cytoplasmic Side Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Endocytosis Pinocytosis Epidermal Growth Factor Catabolic Process Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways	Golgi Associated Vesicle Biogenesis
GWAS	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 25961943 ) LDL cholesterol ( 24097068 25961943 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 33339817 )
Entrez ID	27131
HPRD ID	10439
Ensembl ID	ENSG00000089006
Uniprot IDs	Q6P5V6 Q9Y5X3
PDB IDs	1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z 8A1G 8ABQ 8AFZ
GO Terms Enriched among Interactors ?	Cytoplasmic Vesicle Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Endocytosis Clathrin Complex Receptor-mediated Endocytosis Clathrin Light Chain Binding Sorting Endosome Protein Localization To Lysosome Import Into Cell Double-stranded RNA Binding Clathrin-coated Pit Protein Folding Intracellular Protein Localization Protein Localization To Vacuole Cytoplasm Endosomal Transport Clathrin-coated Endocytic Vesicle Unfolded Protein Binding Cytoplasmic Vesicle Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Clathrin-dependent Endocytosis Protein Folding Chaperone Complex Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Otic Placode Development Basal Dendrite Development