FBXO8

Name	F-box protein 8
Structure	No pdb structure
Novel Interactors	1 novel interactors: GPM6A
Interactors	7 interactors: CDK4 GSTP1 HIF1A MTOR MYC SKP1 TRIP13
GO Annotations	Cellular Component	Ubiquitin Ligase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of ARF Protein Signal Transduction
GWAS	Chin dimples ( 27182965 ) Copper levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 )
Entrez ID	26269
HPRD ID	07293
Ensembl ID	ENSG00000164117
Uniprot IDs	A0A0S2Z5D1 D6RJ92 Q9NRD0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Fibroblast Proliferation Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxygen Levels Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Positive Regulation Of Glycolytic Process Response To External Biotic Stimulus Regulation Of Myeloid Cell Differentiation Positive Regulation Of ATP Metabolic Process Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Population Proliferation Apoptotic Process Positive Regulation Of Epithelial Cell Migration Cellular Developmental Process Response To Oxygen Levels Negative Regulation Of Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Negative Regulation Of Intracellular Signal Transduction SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Epithelial Cell Migration Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Cell Development Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Nitric Oxide Storage E-box Binding Regulation Of Lymphocyte Apoptotic Process Intracellular Iron Ion Homeostasis Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Euchromatin Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Transcription Initiation By RNA Polymerase II Programmed Cell Death Cell Death Regulation Of Epithelial Cell Proliferation