NGEF

Name	neuronal guanine nucleotide exchange factor
Structure	No pdb structure
Novel Interactors	4 novel interactors: SEPTIN2 TTK USP25 YIPF3
Interactors	16 interactors: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning
Pathways	NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Contrast sensitivity ( 24152035 ) Heel bone mineral density ( 28869591 30598549 ) Parkinson's disease ( 32201043 ) Pursuit maintenance gain ( 29064472 ) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260 ) Sudden cardiac arrest ( 30169657 ) Superior temporal sulcus banks volume ( 31530798 )
Entrez ID	25791
HPRD ID	10442
Ensembl ID	ENSG00000066248
Uniprot IDs	B4DDI2 Q8N5V2
PDB IDs	Not available