RASGRP3

Name	RAS guanyl releasing protein 3
Structure	No pdb structure
Novel Interactors	1 novel interactors: DYNC2LI1
Interactors	11 interactors: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Kinase Binding Diacylglycerol Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding
	Biological Process	MAPK Cascade Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
GWAS	Albumin-globulin ratio ( 29403010 ) Bronchopulmonary dysplasia in preterm infants ( 30113228 ) Hypertension (young onset) ( 19421330 ) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287 ) Metabolite levels ( 23823483 ) Multiple system atrophy (pathologically confirmed) ( 27629089 ) Non-albumin protein levels ( 29403010 ) Non-response to antidepressants and depression ( 27622933 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 19838193 23273568 26663301 27399966 28714469 33272962 )
Entrez ID	25780
HPRD ID	15213
Ensembl ID	ENSG00000152689
Uniprot IDs	Q8IV61
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Positive Regulation Of Establishment Of Protein Localization Kinase Activity Cell Activation Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Peptidyl-serine Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Signaling Pathway Regulation Of Protein Transport Fc Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Protein Kinase Activity Regulation Of Protein Localization Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Cytosol Leukocyte Activation Positive Regulation Of Insulin Secretion Positive Regulation Of Immune System Process Insulin Receptor Substrate Binding Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Cellular Response To Hormone Stimulus Perinuclear Region Of Cytoplasm Protein Phosphorylation Regulation Of Biological Quality Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process