FMOD

Name	fibromodulin
Structure
Interactors	5 interactors: CFTR FBXO7 TGFB1 TGFB2 TGFB3
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Transforming Growth Factor Beta Receptor Complex Assembly Collagen Fibril Organization
Pathways	Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
GWAS	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297 ) Blood protein levels ( 30072576 ) Obesity-related traits ( 23251661 )
Entrez ID	2331
HPRD ID	02591
Ensembl ID	ENSG00000122176
Uniprot IDs	A0A024R971 B3KS64 Q06828 Q12833
PDB IDs	5MX0
GO Terms Enriched among Interactors ?	Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Odontogenesis Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Secretion Gland Morphogenesis Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Uterine Wall Breakdown Regulation Of Macrophage Cytokine Production Response To Ketone Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Protein Transport Regulation Of Protein Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Epithelial To Mesenchymal Transition Platelet Alpha Granule Lumen Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of SMAD Protein Signal Transduction Regulation Of Enamel Mineralization Positive Regulation Of Cell Division Regulation Of Protein Transport Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Type I Transforming Growth Factor Beta Receptor Binding Regulation Of Cytokine Production Involved In Immune Response Animal Organ Morphogenesis Regulation Of Establishment Of Protein Localization Negative Regulation Of Immune System Process Secondary Palate Development Regulation Of Secretion By Cell Positive Regulation Of Cardiocyte Differentiation Growth Factor Activity Regulation Of Secretion Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Collagen Biosynthetic Process Cytokine Activity Regulation Of Extracellular Matrix Disassembly Response To Steroid Hormone