FDX1

Name	ferredoxin 1
Structure
Novel Interactors	7 novel interactors: BIRC2 BIRC3 CNTN5 CORO2A LILRB2 PBRM1 RDH5
Interactors	5 interactors: CYCS CYP11A1 CYP11B2 FDXR PRKAB2
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin
Pathways	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation
Drugs	Mitotane
GWAS	Cognitive function ( 24684796 ) Coronary artery disease ( 32469254 ) Serum metabolite levels ( 33031748 )
Entrez ID	2230
HPRD ID	00059
Ensembl ID	ENSG00000137714
Uniprot IDs	P10109
PDB IDs	3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I
GO Terms Enriched among Interactors ?	C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination