ALAS2

Name	5'-aminolevulinate synthase 2
Structure
Interactors	4 interactors: BANP GRB2 RABGGTB SUCLA2
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme B Biosynthetic Process Intracellular Iron Ion Homeostasis Erythrocyte Differentiation Intracellular Oxygen Homeostasis Tetrapyrrole Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways	Heme biosynthesis
Drugs	Pyridoxal phosphate Glycine
GWAS	Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 )
Entrez ID	212
HPRD ID	02356
Ensembl ID	ENSG00000158578
Uniprot IDs	P22557
PDB IDs	5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH
GO Terms Enriched among Interactors ?	Guanyl-nucleotide Exchange Factor Adaptor Activity Grb2-EGFR Complex Succinyl-CoA Pathway Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (ADP-forming) Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Prenyltransferase Activity Succinyl-CoA Catabolic Process Neurotrophin TRKA Receptor Binding Protein Geranylgeranylation Branching Involved In Labyrinthine Layer Morphogenesis Catalytic Activity Prenyltransferase Activity Protein Prenylation Succinyl-CoA Metabolic Process Succinate Metabolic Process Insulin Receptor Substrate Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity