EPB42

Name	erythrocyte membrane protein band 4.2
Structure
Interactors	13 interactors: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cortical Cytoskeleton Cell Periphery Ankyrin-1 Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Monoatomic Ion Homeostasis Multicellular Organismal-level Iron Ion Homeostasis
Diseases	Hereditary spherocytosis (SPH)
GWAS	Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Mean spheric corpuscular volume ( 32888494 )
Entrez ID	2038
HPRD ID	01517
Ensembl ID	ENSG00000166947
Uniprot IDs	P16452
PDB IDs	7TVZ 7TW0 7TW1 7TW3 7TW5 7TW6 7UZS 7V0K 7V0Q 8CS9 8CSL 8CSW 8CTE
GO Terms Enriched among Interactors ?	Spectrin Binding Spectrin-associated Cytoskeleton Structural Constituent Of Cytoskeleton Basolateral Plasma Membrane Cortical Cytoskeleton Regulation Of Actin Filament-based Process Ankyrin-1 Complex Monoatomic Anion Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Cytoskeleton Organization A Band BLOC-1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of Actin Cytoskeleton Organization Z Disc Cytoskeletal Anchor Activity Actin Cytoskeleton Organization Organelle Organization Enzyme Binding M Band Intracellular Monoatomic Ion Homeostasis Regulation Of Biological Quality Intracellular Monoatomic Cation Homeostasis Homeostatic Process Actin Filament-based Process Bicarbonate Transport Erythrocyte Development Actin Filament Capping Protein-membrane Adaptor Activity Monoatomic Cation Homeostasis Protein Localization To Plasma Membrane Monoatomic Ion Homeostasis Negative Regulation Of Actin Filament Depolymerization Localization Within Membrane Intracellular Chemical Homeostasis Regulation Of Cytoskeleton Organization Osteoclast Differentiation Protein Localization To Cell Periphery Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Protein Localization To T-tubule PH Elevation Regulation Of Actin Filament Organization Endomembrane System Cellular Homeostasis Regulation Of Interleukin-12 Production Myeloid Cell Development Cytoskeletal Protein Binding Regulation Of Organelle Organization