C9orf72

Name	C9orf72-SMCR8 complex subunit
Structure
Interactors	11 interactors: APP COIL CRX EIF2B2 HMG20A POP7 REL SRPK1 SYN3 TRIM73 VRTN
GO Annotations	Cellular Component	P-body Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Membrane Axon Dendrite Growth Cone Cytoplasmic Vesicle Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Cell Projection Neuron Projection Perikaryon Axonal Growth Cone Main Axon Autolysosome Synapse Flemming Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol Atg1/ULK1 Kinase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Regulation Of Protein Localization Stress Granule Assembly Negative Regulation Of Exocytosis Axon Extension Negative Regulation Of Immune Response Autophagosome-lysosome Fusion Regulation Of Synaptic Vesicle Cycle Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly
GWAS	Amyotrophic lateral sclerosis ( 19734901 20801718 22959728 24931836 25442119 27455348 29566793 30976013 ) Amyotrophic lateral sclerosis (sporadic) ( 28931804 ) Delirium ( 29631748 ) Metabolite levels ( 23823483 ) PCA3 expression level ( 23555189 )
Entrez ID	203228
HPRD ID	12975
Ensembl ID	ENSG00000147894
Uniprot IDs	Q96LT7
PDB IDs	6LT0 6V4U 7MGE 7O2W