SLC26A3

Name	solute carrier family 26 member 3
Structure
Novel Interactors	1 novel interactors: MET
Interactors	2 interactors: NHERF1 NHERF2
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Sperm Midpiece
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Antiporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Bicarbonate Transport Oxalate Transport Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways	Inorganic anion exchange by SLC26 transporters Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
GWAS	Behavioural changes in frontotemporal lobe dementia ( 29724592 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Inflammatory bowel disease ( 28067908 ) Ulcerative colitis ( 19122664 19915573 28067908 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Entrez ID	1811
HPRD ID	00544
Ensembl ID	ENSG00000091138
Uniprot IDs	P40879
PDB IDs	7XUH 7XUJ 7XUL 8IET
GO Terms Enriched among Interactors ?	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Phosphatase Binding Beta-catenin Binding Hepatocyte Growth Factor Receptor Activity Renal Phosphate Ion Absorption Protein Localization To Plasma Membrane Molecular Adaptor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Morphogenesis Of An Epithelium Identical Protein Binding Hepatocyte Growth Factor Receptor Signaling Pathway Endomembrane System Protein Localization To Cell Periphery Apical Plasma Membrane Protein Localization To Membrane Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Signaling Receptor Binding Intracellular Phosphate Ion Homeostasis Tissue Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Plasma Membrane Protein Complex Stereocilium Tip