CYP51A1

Name	cytochrome P450 family 51 subfamily A member 1
Structure
Novel Interactors	2 novel interactors: GRM3 STT3B
Interactors	3 interactors: SHANK3 TMUB1 ZNF420
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Negative Regulation Of Amyloid-beta Clearance
Pathways	Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs	Tioconazole Itraconazole Levoketoconazole (S)-econazole
GWAS	Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Lifespan ( 25918517 ) Pulse pressure ( 30578418 )
Entrez ID	1595
HPRD ID	03381
Ensembl ID	ENSG00000001630
Uniprot IDs	Q16850
PDB IDs	3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ 8SBI 8SS0
GO Terms Enriched among Interactors ?	Postsynaptic Membrane Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic ERAD Pathway Group II Metabotropic Glutamate Receptor Activity Guanylate Kinase-associated Protein Clustering Oligosaccharyl Transferase Activity Dendritic Spine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Postsynaptic Density Neuron Projection Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Response To Endoplasmic Reticulum Stress Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity GABAergic Neuron Differentiation Neurotransmitter-gated Ion Channel Clustering Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Oligosaccharyltransferase Complex B Oligosaccharyltransferase Complex Auditory Behavior Regulation Of Long-term Synaptic Depression G Protein-coupled Glutamate Receptor Signaling Pathway Mechanosensory Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Protein N-linked Glycosylation Via Asparagine Cellular Response To Stress Positive Regulation Of Long-term Synaptic Potentiation Proteasomal Protein Catabolic Process Postsynaptic Specialization Organization Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity