DHRS4

Name	dehydrogenase/reductase 4
Structure
Interactors	1 interactors: PEX5
GO Annotations	Cellular Component	Nucleus Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Alcohol Dehydrogenase [NAD(P)+] Activity 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Identical Protein Binding All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Alcohol Metabolic Process Steroid Metabolic Process Ketone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways	RA biosynthesis pathway Peroxisomal protein import Peroxisomal protein import
Drugs	Vitamin A
GWAS	Bipolar disorder ( 20351715 )
Entrez ID	10901
HPRD ID	07484
Ensembl ID	ENSG00000157326
Uniprot IDs	F5GWZ1 Q9BTZ2
PDB IDs	3O4R
GO Terms Enriched among Interactors ?	Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Receptor Recycling Peroxisome Organization Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Protein Transmembrane Transport Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Protein Tetramerization Cellular Response To Reactive Oxygen Species Neuromuscular Process Mitochondrial Membrane Organization Peroxisome Lipid Modification Central Nervous System Neuron Differentiation Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Neuron Migration Macroautophagy Positive Regulation Of Developmental Growth Response To Reactive Oxygen Species Establishment Of Protein Localization To Membrane