ALYREF

Name	Aly/REF export factor
Structure
Interactors	13 interactors: AKT1 CEBPA DDX39B ESR1 FOXP1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A
GO Annotations	Cellular Component	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding C5-methylcytidine-containing RNA Reader Activity
	Biological Process	Osteoblast Differentiation MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
GWAS	No GWAS studies recorded
Entrez ID	10189
HPRD ID	09168
Ensembl ID	ENSG00000183684
Uniprot IDs	E9PB61 Q86V81
PDB IDs	3ULH 7ZNJ 7ZNK
GO Terms Enriched among Interactors ?	Nucleoplasm MRNA Transport RNA Transport Transcription Export Complex MRNA Export From Nucleus RNA Export From Nucleus Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Cell Development Positive Regulation Of Cell Population Proliferation RNA Metabolic Process Nuclear Export Osteoblast Differentiation Mononuclear Cell Differentiation T Cell Differentiation Leukocyte Differentiation Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Gene Expression Nitric-oxide Synthase Regulator Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Animal Organ Development Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Transcription Regulator Complex Lymphocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Organ Growth Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Tumor Necrosis Factor Myelin Maintenance Nucleus T Cell Activation Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Osteoblast Development Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Factor Activity