PREB

Name	prolactin regulatory element binding
Structure
Novel Interactors	1 novel interactors: RAB10
Interactors	2 interactors: SMAD1 TGFBR1
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Binding
	Biological Process	Regulation Of COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating COPII-coated Vesicle Cargo Loading
Pathways	COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER
GWAS	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	10113
HPRD ID	16216
Ensembl ID	ENSG00000138073
Uniprot IDs	B5MC98 Q05DB2 Q9HCU5
PDB IDs	5TF2
GO Terms Enriched among Interactors ?	I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Vasculature Development Mesodermal Cell Fate Commitment Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Osteoblast Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Fate Commitment Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Cellular Response To Growth Factor Stimulus Regulation Of Vasculature Development Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Response To Growth Factor Ubiquitin Protein Ligase Binding SMAD Protein Complex Positive Regulation Of Cell Projection Organization DEAD/H-box RNA Helicase Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Ventricular Compact Myocardium Morphogenesis Parathyroid Gland Development Germ Cell Migration Transforming Growth Factor Beta Receptor Activity Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity, Type I Insulin-responsive Compartment Primary MiRNA Binding Coronary Artery Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Secretory Vesicle Pattern Specification Process Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation