TUBA1A - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACVR1B	activin A receptor type 1B	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin	ATP Fostamatinib
Novel	AMHR2	anti-Mullerian hormone receptor type 2	Signaling by BMP	ATP	46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
Novel	ANXA7	annexin A7
Novel	ARL3	ARF like GTPase 3	Trafficking of myristoylated proteins to the cilium	2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate
Novel	ATXN3	ataxin 3	Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel	B4GALT1	beta-1,4-galactosyltransferase 1	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes CDG-2d Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation	N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid	Congenital disorders of glycosylation (CDG) type II
Novel	BTG1	BTG anti-proliferation factor 1	FOXO-mediated transcription of cell cycle genes
Novel	C8orf33	chromosome 8 open reading frame 33
Novel	CDKN1A	cyclin dependent kinase inhibitor 1A	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	Valproic acid Arsenic trioxide	Cervical cancer
Novel	CDKN2A	cyclin dependent kinase inhibitor 2A	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Nuclear events mediated by NFE2L2		Chronic myeloid leukemia (CML) Non-small cell lung cancer Malignant islet cell carcinoma Adult T-cell leukemia Esophageal cancer Glioma Pancreatic cancer Nasopharyngeal cancer Hepatocellular carcinoma Squamous cell carcinoma Penile cancer Oral cancer Malignant melanoma Burkitt lymphoma Gallbladder cancer Bladder cancer Laryngeal cancer Cholangiocarcinoma Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
Novel	CEP20	centrosomal protein 20
Novel	CLIP1	CAP-Gly domain containing linker protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by LTK in cancer
Novel	CNP	2'',3''-cyclic nucleotide 3'' phosphodiesterase
Novel	CPEB2	cytoplasmic polyadenylation element binding protein 2
Novel	CXCR1	C-X-C motif chemokine receptor 1	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Ketoprofen
Novel	CYLD	CYLD lysine 63 deubiquitinase	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling		Brooke-Spiegler syndrome Multiple familial trichoepithelioma Familial cylindromatosis
Novel	DAG1	dystroglycan 1	Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Matriglycan biosynthesis on DAG1		Limb-girdle muscular dystrophy (LGMD)
Novel	DUSP23	dual specificity phosphatase 23		4-Nitrophenyl Phosphate
Novel	EGFR	epidermal growth factor receptor	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Respiratory syncytial virus (RSV) attachment and entry Developmental Lineage of Mammary Gland Myoepithelial Cells	Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Poziotinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib Mobocertinib Almonertinib Amivantamab	Laryngeal cancer Cervical cancer Oral cancer Gastric cancer Choriocarcinoma Esophageal cancer Glioma Bladder cancer
Novel	EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1

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