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Novel |
AGFG1 |
ArfGAP with FG repeats 1 |
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
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Novel |
ATOH1 |
atonal bHLH transcription factor 1 |
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Novel |
BAIAP2L2 |
BAR/IMD domain containing adaptor protein 2 like 2 |
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Novel |
DRD3 |
dopamine receptor D3 |
- Dopamine receptors
- G alpha (i) signalling events
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- Ziprasidone
- Cabergoline
- Ropinirole
- Dihydroergotamine
- Olanzapine
- Clozapine
- Sulpiride
- Loxapine
- Remoxipride
- Pramipexole
- Chlorpromazine
- Buspirone
- Haloperidol
- Amoxapine
- Lisuride
- Apomorphine
- Flupentixol
- Dopamine
- Ergoloid mesylate
- Pimozide
- Domperidone
- Pergolide
- Bromocriptine
- Quetiapine
- Levodopa
- Aripiprazole
- Chlorprothixene
- Paliperidone
- Yohimbine
- Methotrimeprazine
- Iloperidone
- Rotigotine
- Norclozapine
- Cariprazine
- Mianserin
- Asenapine
- Amisulpride
- Sarizotan
- Sumanirole
- Nandrolone decanoate
- Captodiame
- AS-8112
- Blonanserin
- Pipamperone
- Tianeptine
- Dihydro-alpha-ergocryptine
- Epicriptine
- Pardoprunox
- Piribedil
- Tiapride
- Dihydroergocristine
- Aripiprazole lauroxil
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Novel |
EEF1A1 |
eukaryotic translation elongation factor 1 alpha 1 |
- Eukaryotic Translation Elongation
- Eukaryotic Translation Elongation
- Peptide chain elongation
- HSF1 activation
- Neutrophil degranulation
- Protein methylation
- Chaperone Mediated Autophagy
- SARS-CoV-1 modulates host translation machinery
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- Zinc
- Guanosine-5'-Diphosphate
- Copper
- Artenimol
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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Novel |
ERG28 |
ergosterol biosynthesis 28 homolog |
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Novel |
EXOSC4 |
exosome component 4 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- mRNA decay by 3' to 5' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- Major pathway of rRNA processing in the nucleolus and cytosol
- Nuclear RNA decay
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Novel |
KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
- Cardiogenesis
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- Coenzyme A
- S-Acetyl-Cysteine
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Novel |
MAPRE1 |
microtubule associated protein RP/EB family member 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
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Novel |
NID2 |
nidogen 2 |
- Laminin interactions
- Laminin interactions
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Novel |
PARK7 |
Parkinsonism associated deglycase |
- SUMOylation of transcription cofactors
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
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Novel |
PKM |
pyruvate kinase M1/2 |
- Neutrophil degranulation
- Negative Regulation of CDH1 Gene Transcription
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- Pyruvic acid
- L-Phospholactate
- 2-Phosphoglycolic Acid
- 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
- 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
- 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
- Indoprofen
- Copper
- Polydatin
- Artenimol
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Novel |
POLE4 |
DNA polymerase epsilon 4, accessory subunit |
- Recognition of DNA damage by PCNA-containing replication complex
- PCNA-Dependent Long Patch Base Excision Repair
- Termination of translesion DNA synthesis
- HDR through Homologous Recombination (HRR)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- DNA replication initiation
- Activation of the pre-replicative complex
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Novel |
PYGL |
glycogen phosphorylase L |
- Neutrophil degranulation
- Glycogen breakdown (glycogenolysis)
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- Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
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Novel |
REL |
REL proto-oncogene, NF-kB subunit |
- Activation of NF-kappaB in B cells
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Novel |
SAP18 |
Sin3A associated protein 18 |
- HDACs deacetylate histones
- NoRC negatively regulates rRNA expression
- mRNA Splicing - Major Pathway
- Potential therapeutics for SARS
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Novel |
SAV1 |
salvador family WW domain containing protein 1 |
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Novel |
SORBS3 |
sorbin and SH3 domain containing 3 |
- Smooth Muscle Contraction
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Novel |
TBX15 |
T-box transcription factor 15 |
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Novel |
TLE1 |
TLE family member 1, transcriptional corepressor |
- Formation of the beta-catenin:TCF transactivating complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Deactivation of the beta-catenin transactivating complex
- Repression of WNT target genes
- Repression of WNT target genes
- Negative Regulation of CDH1 Gene Transcription
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