KEAP1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	Ethanol oxidation	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Novel	ARPC1B	actin related protein 2/3 complex subunit 1B	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Novel	BNIP3L	BCL2 interacting protein 3 like	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Novel	CARM1	coactivator associated arginine methyltransferase 1	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Novel	ERBIN	erbb2 interacting protein	Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Novel	LONP1	lon peptidase 1, mitochondrial	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Novel	PANX1	pannexin 1	Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Probenecid
Novel	RTN4R	reticulon 4 receptor	Axonal growth inhibition (RHOA activation)
Novel	S1PR2	sphingosine-1-phosphate receptor 2	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Novel	SDC1	syndecan 1	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Novel	SENP1	SUMO specific peptidase 1	SUMO is proteolytically processed RHOF GTPase cycle
Novel	SLC5A5	solute carrier family 5 member 5	Thyroxine biosynthesis Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC-mediated transport of inorganic anions	Iodine Potassium perchlorate	Thyroid dyshormonogenesis; Dyshormogenetic goiter
Novel	VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Novel	ZNF177	zinc finger protein 177
Novel	ZNF266	zinc finger protein 266	Generic Transcription Pathway
	AK4	adenylate kinase 4	Interconversion of nucleotide di- and triphosphates
	AMER1	APC membrane recruitment protein 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Neddylation KEAP1-NFE2L2 pathway		Osteopathia striata with cranial sclerosis
	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A
	ASTN1	astrotactin 1
	ATF5	activating transcription factor 5	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)	Pseudoephedrine

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